Izinzuzo ze-emulsation ye-ultrasonic zama-emulsions amahle ezimonyo nezimonyo zemithi

Ngabe usalwa nokhilimu ohlukanisa ngokushesha ukwedlula inhlebo yehhovisi nama-serums aphenduka iziqhingi ezincane zamafutha ebusweni?

Uma "ama-emulsions angazinzi" kuzwakala sengathi ikhanda lakho lansuku zonke kwilebhu, awunadwa - amafomula aphulukana, crystallize, noma ulahlekelwe ukuthungwa yisikhathi sokudonsa, isabelomali nokubekezela.

Lesi singeniso sihamba ngendlela ye-emulsation ye-ultrasonic sisiza kanjani ukudala i-Ultra - ama-emulsion amahle agcina ama-actives akho ahlakazeka ngokulinganayo, ukufakwa kwakho kweshalofini, neshalofu lakho - Impilo yakho ye-QA ifushane.

Ukusuka kosayizi wesayizi wezinhlayiyana ukuze uthuthukise ama-bioavailability, uzobona ukuthi kungani ama-formatators kuzo zombili izimonyo kanye nemithi yezemithi ayashintshwa kusuka ku-homogenization yendabuko kuya phezulu - ukusebenza kahle kwezinhlelo ze-ultrasonic.

Kulabo abadinga amanani anzima nemikhuba yejika, ukuhlaziya kwemboni kwakamuva kuhlinzeka ngemininingwane yenqubo eningiliziwe, ukuqhathanisa kwe-ROI, kanye namanani okutholwa kwemakethe:Umbiko Wezimakethe Wokusebenza kwe-Ultrasonic.

Thatha ikhofi; I-emulsion yakho elandelayo elandelayo ingaqala lapha.

💧 Ukulawulwa kosayizi we-Droplet okuthuthukile isikhathi eside - ama-emulsions ahlala njalo nezokwelapha

I-Ultrasonic emulsation isebenzisa ukuphakama okuphezulu - imvamisa ye-cavitation ukukhiqiza amaconsi amahle kakhulu futhi afanayo, athuthukisa kakhulu ukuqina kwe-emulsion kumakhilimu, ama-lotion, okujova kanye nokumiswa. Ukusatshalaliswa kosayizi we-Droplet kungaguquki ukubambezeleka kwama-coalescence, ukuhlukaniswa kwesigaba kanye nokhilimu, ukunwebisa impilo yeshelufu nokugcina ukusebenza komkhiqizo kusuka ekukhiqizeni ukuqeda ukusetshenziswa.

Lokhu kulawulwa okuqondile kwe-Droplet kubalulekile kwizimonyo zezimonyo zamaphrofayili ezinzwa abushelelezi kanye nasemikhakheni ye-DOSE Unipromity. Ngezinhlelo ze-ultrasonic, amakhemikhali angabonisa amapharamitha anjenge-amplitude, isikhathi namandla okuthola izinhlaka zethagethi eziqondiwe kusuka ku-micron kuya kwe-nano scale ngemiphumela ephindaphindekayo, enokalisiwe.

1. Indlela ye-Stration ye-Ultrasonic ye-Emulsion yokwakheka okuhle

Ngesikhathi se-emulsation e-ultrasonic, ukushintshana okuphezulu - Futhi okuphansi - amagagasi wengcindezi akha ama-microbubbles akhula ngokushesha futhi awe. Leavituation yakha amandla amakhulu we-shear wendawo kanye nama-microjets aphula amaconsi kawoyela ngempumelelo kumayunithi amancane kakhulu.

• I-Shead yasendaweni eya kuzinkulungwane ze-S⁻¹ eduze ne-sonotrode
• Ukuphazamiseka okusebenzayo kwama-rodoplet agglomerates kanye namaqoqo
• Ukwakheka kokusatshalaliswa kosayizi amadrayivu (polydispersity aphansi)
• Ukuvuselelwa okwenziwe ngcono kwe-interfacial ngabakwaSurfactants, ukukhulisa ukuqina kwe-kinetic

2. Izinzuzo zokuqina kokhilimu, ama-serums kanye nokujova ama-emulsions

Amaconsi amahle futhi afanayo atholwe yi-ultrasound akhulisa ngokuqina komzimba womabili amafutha - ku - amanzi namanzi - ku- - ama-oyela amasistimu. Amaconsi amancane anciphise ukudideka kanye ne-velocities ekhilimu, futhi indawo eyandayo ye-interfacial isiza ama-surfactants akha amafilimu anamandla.

• Ingozi eyehlisiwe yokuhlukaniswa kwesigaba ngesikhathi sokugcina nokuthumela
• Ukuthambekela okuphansi ukwakha izindandatho zamafutha abonakalayo noma i-sediment
• Ukuvumelana kokubonana nokubukeka kwempilo eshalofini
• Ukusebenza okucatshangelwa ngokwengeziwe ngaphansi kokuhlolwa kokushisa kwama-cycling

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Amakhemikhali wezimonyo ancike ku-emulsation ye-ultrasonic ukuze acwenge ukuthungwa, ukusakazeka nokubukeka. Amaconsi amahle adala isikhumba esinethezeka ngokwengeziwe ngokuzwakala ngokuncipha okuncane nokumunca ngokushesha, ngenkathi ukufana kuthuthukisa izakhiwo ezibonakalayo ezifana ne-transcupency kanye ne-gloss.

4. Ukulawulwa kwenqubo kanye nokuvela kabusha kwizimboni ezilawulwayo

Emikhakheni nakwezokwelapha - Ibanga lezimonyo, Ukulawulwa kwenqubo eqinile kubalulekile. Izinhlelo ze-Ultrasonic zivumela ukulungiswa okunembile kwamandla, imvamisa kanye nesikhathi sokucubungula ukufeza osayizi be-Droplet osayizi, ukusekela ukuqinisekiswa kanye nokulandela umthetho wokulawula.

• Amapharamitha ahlelekayo wezinqubo ezijwayelekile zokusebenza (ama-sops)
• Amaphrothokholi abukeka ebhekwe kusuka ebhentshini kuya kumshayeli wendiza ukukhiqiza okugcwele
• I-LOT ethuthukisiwe - Ukuvumelana okuningi ku-Discive DOSAGE amafomu
• Ukuhambisana ku - umugqa usayizi wokuqapha usayizi wokuqapha

🧴 I-bioavailent esebenzayo esebenzayo esebenzayo ngokusebenzisa i-nanoemulsions ekhiqizwa yi-ultrasonically

I-emulsation ye-ultrasonic yenza ukukhiqizwa kwama-nanoemulsions-emulsions ngama-droplet osayizi ngokuvamile angaphansi kwama-200 Indawo enkulu yokuzijabulisa kanye nosayizi omncane weconsi kukhuthaza ukuqedwa okungcono, ukumuncwa kanye nokungena ngesikhumba, izithiyo zesisu noma zesisu sezimonyo nezimonyo zemithi.

Lezi ze-nanoemulsions ukweseka ukukhishwa okulawulwayo, ukulethwa okuhlosiwe kanye nokuvikelwa okuthuthukile kwezithako ezibucayi njengamavithamini, ama-peptides, ukukhishwa kwe-botanical kanye nezidakamizwa ze-lipophilic, ngokunemba komkhiqizo ngokuqondile.

1. Ukuthi amaconsi asayizi anyuselwa kanjani akhulisa ukumuncwa kanye nokungena ngaphakathi

I-Nanoemulsions ihlinzeka ngendawo enkulu engaphezulu yeyunithi ngayinye umthamo, osheshise ukuchithwa futhi unyuse ukuthintana nolwelwesi lwebhayoloji. Usayizi omncane we-Droplet futhi ungasiza ukusebenzisana okukhulu okusondele kakhulu ngama-lipids wesikhumba noma izindawo ze-mucosal, ukuthuthukisa permonce kanye nokuthathwa.

• Ukuthuthuka okuthuthukisiwe kwama-hydrophobic API (izithako ezisebenzayo zemithi)
• Ukuhanjiswa kwesikhumba okuthuthukile nokulethwa kwama-transdermal kuma-serums wezimonyo
• I-Bioavailability engcono ye-Oral Lipid - Izinhlelo ezisuselwa kwezidakamizwa ezisuselwa
• Ukuncishiswa kwethamo okungenzeka ngaphandle kokuyekethisa ukusebenza ngempumelelo

2. Ukuvikelwa kwama-molecule abucayi kusuka ekudleni kwama-degnatation

Ama-actives avumelayo ngaphakathi kwamaconsi akhiqizwe yi-ultrasonically avikeke ekukhanyeni, umoya-mpilo kanye ne-hydrolysis. Ungqimba kawoyela no-surfantant unikela nge-microenvelonction enciphisa ukucekelwa phansi futhi andise impilo yokusebenza kwama-molecule angazinzile.

• Ukuqina okuthuthukisiwe kwamavithamini (a, c, e) nama-antioxidants
• Ukuvikelwa kwama-peptides, ama-enzyme kanye nokukhishwa kwe-botanical
• Ukulahleka kwehlise umsebenzi ngesikhathi sokugcina nokusabalalisa
• Ukusebenza okuthembekile okwethembekile okuthe xaxa - ishalofu - imikhiqizo yempilo

I-3. I-Insight Insight: Usayizi we-Droplet vs.

Ubudlelwano obuphakathi kosayizi we-droplet kanye ne-bioavailability kungaboniswa yidatha ejwayelekile yokuhlola ngokuqhathanisa ama-emulsions ajwayelekile kanye nama-nanoemulsonic we-ultrasonic we-lipophilic API. Amaconsi amancane amancane ahlangana ngokuhlale ahambisana ne-bioavailability ephakeme ephakeme, esekela ukusetshenziswa kwamasu we-ultrasound design.

4. Izicelo ku-Dermal, Transdermal kanye nezinhlelo zokulethwa ngomlomo

I-Ultrasonic Nanoemulsions isetshenziswa kabanzi kuyo yonke imizila yokulethwa kwezihloko nangezihlelo. Ekunakekelweni kwesikhumba, bathuthukisa ukungena kwe-anti - ukuguga, ukugqamisa kanye ne-anti - ama-inflammatory agents. Emikhakheni, basekela ukuthuthukiswa kwe-bioavailobility yomlomo futhi kungakhiwa ukulethwa okuhlosiwe.

🧪 Ukucutshungulwa kwe-Ultrasonic kokusetshenziswa okuncishisiwe kwe-surfisent kanye namalebula okuhlanza okuhlanza

I-emulsation ye-ultrasonic inganciphisa kakhulu ukugxila okudingekayo okudingekayo kokuhlushwa okudingekayo ngoba i-cavitation ihlinzeka ngokuhlakazeka okunamandla kwemishini kanye nendawo ephezulu yokungezwani. Amakhemikhali angagcina noma athuthukise ukuqina okunama-emulsifers ambalwa kanye ne-CO - ama-surfactants, asekela "ilebula ehlanzekile" izimangalo kanye nokunciphisa amandla okucasuka noma ukuzwela.

Le ndlela izuzisa izimonyo zemvelo kanye nokwakhiwa kwemithi ebucayi, ukuqondanisa nezimfuno zokulawula nezokuthenga zabathengi ze-minimal, kahle -

1. I-Mechanic areCleines yesidingo esisezingeni eliphansi

Ngoba i-ultrasound ikhiqiza amaconsi amahle futhi ikhuthaza ama-adsorpr asebenza kahle esibonakalayo esibonakalayo samanzi e-oyili, kudingeka i-emulsifier encane ukuqinisa ingxenye ethile yevolumu yesigaba esihlakazekile. Ukufakwa kwamandla kunxephezela ukuncishiswa kokuncipha kokudla okuncishisiwe ngokwakha amaconsi amancane athambekele ngokwemvelo ukuze athambekele kwiCoalescence.

• Ukuqhekeka okusebenzayo kwe-Droplet kunciphisa isidingo samazinga aphezulu ashelelayo
• Ukusatshalaliswa okuthuthukisiwe kwe-emulsifier ezindaweni zokuxhumana
• Okungaba khona ukufaka esikhundleni ama-emulsifiers okwenziwa ngezinye izindlela eziphithizelayo
• Ingozi ephansi ye-Foaming iqhathaniswa ne-High - Shear ukuxuba

2. Ukulawula nezinzuzo zokumaketha zamalebula ahlanzekile

Ngemikhiqizo egcizelela imikhiqizo yemvelo noma ye-hypoallenic, ukwehlisa okuqukethwe kwe-surfactant kwenza lula uhlu lwe-ICI futhi kunciphise ukuthunyelwa okulawulwayo. I-Emulsification ye-Ultrasonic isekela izimangalo ezinjengokuthi "Low - Ukucasuka," "Izithako Ezincane" noma "ngaphandle kokuqina okunzima," okuhambisana nokuqina ezigabeni ze-skincare kanye nezigaba ze-skical yemithi.

• Uhlu olufushane lwezithako ezinezithasiselo ezimbalwa ezisebenzayo
• Ukuqondanisa okungcono ngamazinga we-organic kanye nezemvelo
• Isidingo Esinqunyiwe Sokubumbana noma Okuvinjelwe Ama-Surfactants
• Ukuthuthukiswa kwabathengi okuthuthukile kanye nokuma komkhiqizo

I-3. Izindleko nokusebenza kahle kokusebenza kwezimboni

Ama-surfactants kanye ne-CO - Abaqinisi bavame phakathi kwama-excipie abiza kakhulu emulsion. Ngokusebenzisa i-ultrasound ukusika la mazinga, abakhiqizi banganciphisa izindleko ezibonakalayo ngaphandle kokudela ukuqina, futhi kwesinye isikhathi zize zithuthukise ukusebenza ngokulawulwa kweconsi elihle.

⚙️ Amandla - I-Entrasonition Solutions esebenza kahle, e-skali ye-emulsition ye-R & D kanye nokukhiqizwa

Izinhlelo zesimanje ze-ultrasonic zinikeza amandla aphezulu amandla aphezulu ngokuqhathaniswa nokuphezulu kwemishini ephezulu - ama-shear miiners kanye nokuphakama - ingcindezi ye-homogenizer. Amandla alethwa ngqo ku-ketshezi nge-sonotrode, ukunciphisa ukulahleka nokunciphisa amandla izikhathi zokucubungula ezimfushane. Imigomo efanayo ikala kusuka kumavolumu welebhu kuya kuma-reactors wezimboni, okwenza lula ukuthuthukiswa kwenqubo.

Ngokwakheka kohlelo olufanele, izimo ze-cavitation zingaphindwa kaningi kusuka kuma-milliliter kuya kwezinkulungwane zamalitha, kuqinisekiswe ukusebenza okuthembekile emijikelezweni yokuphila komkhiqizo.

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Kwindawo ye-R & D, ama-homogenizer e-benchtop ultrasonic avumela ukuhlolwa okusheshayo kokwakheka kanye namapharamitha enqubo. Abaphenyi bangaguqula ama-amplitude, imodi yokushayela kanye nesikhathi sokucubungula ukubona izimo ezifanele ze-Droplet usayizi, polydispersertity kanye nokuqina.

• Ilungele ukuhlolwa okuncane -
• Isekela ukwakheka kwezindlela zokuhlola (DoE)
• Imijikelezo ye-Iteration esheshayo ye-Emulsions entsha
• Ukudluliselwa kwepharamitha eqondile ku-Pilot - Equipment Equipment

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Izinhlelo zezimboni ze-ultrasonic zisebenzisa amaseli wokugeleza kanye nama-sonotrotro amaningi ukwelapha ukusakazwa okuqhubekayo noma amabhethri amakhulu. Ngokufanisa nobuningi bamandla kanye nesikhathi sokuhlala kusuka kwalebhu ukutshala, isikali se- "Up siqonde futhi sibikezele, sinciphisa ubungozi bokuziphatha okungalindelekile esikalini sokukhiqiza.

I-3. Izinzuzo ze-Energy and Seartion vs Izindlela Zendabuko

I-emulsation ye-ultrasonic imvamisa isebenza ekusetshenzisweni kwamandla okuphansi okuphelele kanye nobunzima obuphansi bokuphezulu - ingcindezi ye-homogenizer. Kunezingxenye ezimbalwa ezinyakazayo, akukho ukuphakama - izimpawu zokucindezela kanye nokugqoka okuphansi, okuholela ekunciphiseni izindleko zokuphumula kanye nokugcina isikhathi sokuphila kwesikhathi.

• Ugqoke izingubo zokwengeza ngokuqhathaniswa nezinhlelo ze-rotor-stator
• Izingxenye ezilinganiselwe ezisebenzisekayo
• Amandla agxile lapho kudingeka khona i-cavitation
• I-compact footprint yokuhlanganiswa emigqeni ekhona

Kungani abahlinzeki be-laboratories kanye nabakhiqizi bakhetha amasistimu we-hanspire we-ultrasonic ama-emulsonion azinzile

Imishini yeHanspire ye-Ultrasonic iye yafuna izimonyo ngezimo ezifunwayo kanye nemithi, ihlanganisa ukuguquguquka kwenqubo, ukuqina kanye nokuqina. Ngamamodeli azinikezele ngocwaningo lwelebhu kanye nokukhiqizwa kwezimboni, amasistimu weHanspire asiza ama-amerotators afinyelela ngokungaguquguquki, isikhathi eside - ama-emulsion ahlala njalo kanye nama-nanoemulsions anokulawulwa kwe-droplet.

Ukusuka ekukhishweni kwe-botanical kuya ku-nano advanced nano - Ukuhlakazeka, Lezi zinhlelo zisekela izinhlelo ezahlukahlukene ngenkathi zihlangana namazinga aphezulu ukuze zithembeke, ukuhlanzeka kanye nokuphindaphinda.

1. Izisombululo zokunemba ze-mosmetic nezokwelapha

Le khasiUkuqina okuphezulu 20Khhz zezimboni ze-ultrasonic homogenizer ze-Meterbs Extraction and Weke - Up Emulsationyakhelwe ukuphatha izisekelo ze-viscous cosmetic kanye nokukhishwa okuyinkimbinkimbi kwamakhambi. Ukusebenza kwayo okuzinzile 20 Khz kanye nokwakha uphondo oluqinile kunika amandla ukukhiqizwa okuthembekile kwe-nanoemulsion, ukuthuthukisa ukukhishwa okusebenzayo nokuzinza okulandelayo kwe-emulsion.

• Ilungele izimonyo zemvelo ne-Dermo - amabanga okugcoba
• Isekela i-ethanol / amanzi namafutha - Ukukhishwa okusekelwe
• Uhambisa ukusatshalaliswa kosayizi we-droplet
• Ilungele ukucubungula okuqhubekayo nokuqhutshwa kwe-batch

2. I-Sonochemistry ethuthukisiwe kanye ne-R & D Ikhono

Yelebhu - ukuthuthukiswa kokukalwa, iUkusebenza okuphezulu kwe-sonogemizer ye-ultrasonic ye-ultrasonic ye-ultrasonic ye-ultrasonienihlinzeka ngokulawulwa okuhlukile nokuguquguqukayo. Inika amandla ukuhlolwa okusheshayo kwama-emulsifiers, izigaba zamafutha kanye nezimo zenqubo, ukusekela kokubili kusenesikhathi - ukwakhiwa kwesigaba kanye nokucwaninga kwesigaba.

3. Ukuqina Kwezimboni, Ukuguquguquka kanye Nesiphambano - Isipiliyoni Sezimboni

Imboni kaHanspire - Amasistimu webanga le-Ultrasonic afakazelwa kwizicelo eziyinselele ezivela ku-Metal Jwowoti ku-Nanomatadium, ekhombisa ukuqina okuqinile nokuqina. Le khasiUkusebenza kahle okuphezulu kwe-20KHZ zezimboni ze-Ultrasonic Metal Metal Methar ye-Liquid AluninumkanyeUkusebenza okuzinzile kwe-homogenizer eqinile ye-nano graphene dissaverity kanye nokukhishwa kwe-CBDkhombisa amandla abo aphezulu - izimo ezifunwayo, ukuhumusha kube yisikhathi eside enokwethenjelwa - ukusebenza kwegama ekusebenzeni kwezimonyo kanye nokusebenza kwemithi.

• Esindayo - umklamo wokusebenza kokusebenza okungu-24/7
• Ubuchwepheshe eNano - Ukuhlakazeka kanye noketshezi oluyinkimbinkimbi
• Injini yokuhlanza okuqondile nokuhlanganiswa
• Amapulatifomu ahlelekile asebenzela izimboni eziningi

Ukugcina

I-emulsification ye-ultrasonic isibe ubuchwepheshe obuhle bokwakhiwa kwezinzile, ukuphakama - - - Ngokubopha i-acoustic acoustic cavitation, abakhiqizi bangakhiqiza amaconsi amahle, afanayo athuthukisa kakhulu ukuqina komzimba, izakhiwo zemizwa nokusebenza okusebenzayo okusebenzayo uma kuqhathaniswa nezindlela ezivamile.

Kumikhiqizo yezimonyo, i-ultrasound isho ukwakheka okubushelelezi, ukumuncwa okuphakeme kanye nokwakheka okuzinzile okuvumelanisa nokuhamba nokugcina isikhathi eside. Emikhakheni, ixhasa ama-bioavailability athuthukisiwe we-actives engenakulungiswa kabi, ukuvikelwa okuthuthukile kwezithako ezibucayi kanye ne-dosing engaguquki. Lezi zinzuzo zitholakala ngenkathi zivame ukunciphisa amazinga asetshenzisiwe, okuholela emalebula ahlanzekile kanye nengozi ephansi yokucasuka.

Amandla - Izinhlelo ezisebenzayo ze-ultrasonic zigcwele kalula kusuka ngelebhu ukutshala, ukwenza lula inqubo yokudluliselwa kwenqubo kanye nokudluliswa kobuchwepheshe. Imishini ekhethekile kaHanspire ekhethekile inikezela ngokuthembekile, ukuphakama - izixazululo zokuqina ezihambelana nokufuna izicelo zokuhlobisa kanye nemithi, okwenza womabili amadizayini womkhiqizo asebenza kahle nezinqubo zokukhiqiza ezisebenzayo.

Imibuzo Ebuzwa Njalo mayelana ne-emulsion ye-ultrasonic

1. Kuyini i-emulsation ye-ultrasonic?

I-emulsation ye-ultrasonic inqubo esetshenziswa ukuphakama - imvamisa umsindo wamagagasi ukudala i-cavitation in ketshezi. Ama-microbubble aphumela awela futhi akhiqize amandla amakhulu we-shear aphula amaconsi amakhulu abe yincane kakhulu, akha ama-emulsions amahle noma ama-nanoemulsions ngokuqina nokusebenza okuthuthukile.

2. Kuhluke kanjani i-endulsation ye-ultrasonic kusuka ku-High - Shear ukuxuba?

Okuphezulu - Ama-Shear Miiners athembela kuma-rotor-stator mechanics kanye nesiphithiphithi ngobuningi, kuyilapho amasistimu e-ultrasonic adala i-cavitation yasendaweni nge-shear ephakeme kakhulu ezingeni le-microscopic. Lokhu kuvumela i-ultrasound ukufezekisa osayizi abancane be-Droplet, ukusatshalaliswa okuncane nokuzinza okungcono ngokugxila okuphansi okuqhubekayo.

3. Kungasetshenziselwa ukusetshenziselwa ukushisa - izithako ezibucayi?

Yebo. Yize i-ultrasound ikhiqiza ukushisa okuthile, izikhathi zokuvezwa zifushane futhi zingalawulwa ngamasistimu wokupholisa kanye nezindlela zokushaya kwenhliziyo. Izakhi eziningi eziqukethe ukushisa - amavithamini abucayi, ama-enzyme kanye nama-botanical akhishwe acutshungulwa ngempumelelo kusetshenziswa izimo ezilawulwa ngokucophelela ze-ultrasonic.

4. Yini osayizi be-droplet abangatholakala ngezinhlelo ze-ultrasonic?

Imishini ye-Ultrasonic ivame ukukhiqiza amaconsi ama-submicron nama-nanoemulsions, imvamisa ebangeni le-50-200 nm ngokuya nge-parameter yenqubo. Usayizi ongafinyeleleka uncike ezintweni ezifana nokwakheka kwesigaba samafutha, uhlelo olusezingeni eliphezulu, okokufaka kwamandla kanye nesikhathi sokucubungula.

I-5. Ingabe ukucaciswa kwe-ultrasonic okulungele ukukhiqizwa okukhulu -

Yebo. Izinhlelo zezimboni ze-ultrasonic zisebenzisa amaseli wokugeleza kanye nezinketho eziningi zenzelwe ukuqhubeka noma ezinkulu - ukucubungula kwe-batch. Ngokufanisa ubungako bamandla kanye nesikhathi sokuhlala kusuka kwaLab - Abakhiqizi bangakwazi ukukala ngokuthembekile kumakhulu noma izinkulungwane zamamitha ngenkathi begcina usayizi weconsi nokuqina.